Human Cell Models Reveal Two Sides to α-Synuclein Inclusions
Dynamic, lipid-rich inclusions of α-synuclein appear toxic, while stable, fibril-rich aggregates seem to protect neurons.
Dynamic, lipid-rich inclusions of α-synuclein appear toxic, while stable, fibril-rich aggregates seem to protect neurons.
A new strategy, which marries nanobodies or misfolded tau to a ubiquitin ligase RING domain, tags tangles for disposal.
The consortium has cranked out dozens of mouse models of late-onset AD for the research community. Strains carry humanized Aβ and tau, and a growing list of risk variants.
A retrospective study finds that gut damage precedes Parkinson’s disease onset, independent of bacterial infection.
This super-sized isoform resists phosphorylation and aggregation, and occurs in cerebellum and brainstem, regions largely spared from tau pathology.
The indefatigable Colombian neurologist leaves behind a legacy of Alzheimer’s prevention research, which, at the time of his passing, stands on the cusp of success.
Kynurenine curbs lactate production in astrocytes, which then fail to nourish neurons. Shutting down kynurenine production rescued cognition in AD mouse models.
Pathways of autophagy, ubiquitination, endocytosis, and glycolysis changed in Alzheimer’s. Treatment with the drug atomoxetine normalized some of them.
On September 10, Francisco Lopera died of cancer in Medellin, Colombia. He was widely beloved. Lopera helped pioneer prevention trials of disease-modifying drugs after years spent assembling information on the world’s largest known kindred of autosomal-dominant Alzheimer’s disease caused by the E280A Paisa mutation in presenilin 1.
Sporadic Alzheimer’s is a complex disease caused by a convergence of genetic, environmental, and health factors that may vary from person to person. To model this heterogeneity and pave the way for medicines targeting different manifestations, the MODEL-AD consortium has been churning out lines strapped with different AD risk variants. Recent published findings and presentations at AAIC highlight a growing catalogue of mouse models widely available to researchers.
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